HU58® (Bacillus subtilis)

Description

We market the special strain of Bacillus subtilis as HU58®
Spore probiotics are widely used in humans as dietary supplements, in animals as growth promoters and competitive exclusion agents, and finally, in aquaculture to improve growth and disease resistance.

The Bacillus subtilis strain developed by us and sold under the brand HU58® is more stable in the acidic environment of the stomach, can grow and sporulate in the anaerobic gastrointestinal tract, has high sporulation efficiency, forms biofilms that enhance intestinal colonization, and produces surfactant that improves intestinal adherence. The ability of B. subtilis bacteria and spores to stimulate intestinal epithelial cells and GALT (gut-associated lymphoid tissue), together with the absence of any signs of toxicity both in vitro and in vivo, suggests that B. subtilis ingestion could have beneficial effects in strengthening the immune system and perhaps preparing it for an adaptive immune response.

The benefits of HU58®

• Bacillus subtilis is one of the dominant components of the normal gut microflora
• B. subtilis spores are highly resistant to temperature, extreme pH, gastric acid, bile, and solvents, therefore maintaining viability in the gut. B. subtilis can be stored for long periods of time without refrigeration
• B. subtilis is the most productive species where 4-5% of its genome synthesizes antimicrobials from which 66 types of antibiotics can be manufactured. These antimicrobial substances are effective against a wide spectrum of pathogens.
• In the gut, B. subtilis spores not only germinate but also resporulate from vegetative cells. B. subtilis sporulation plays an important role in the development of GALT (gut-associated lymphoid tissue), which is important for both adaptive and innate immunity.
• B. subtilis improves protection against pathogens by stimulating non-specific and specific immunity
• Bacillus subtilis restores balance in the gut microflora: growth of beneficial Bifidobacterium, Lactobacillus, Butyricicoccus spp. increases while the growth of gut-harmful Acinetobacter, Ruminococcus, Clostridium, and Veillonella species decreases
• Bacillus subtilis helps preserve intestinal barrier integrity, decreases endotoxin concentration, and reduces intestinal inflammation
• HU58® in particular increases levels of short-chain fatty acids (SCFAs), mainly butyrate, which has beneficial effects on the development of a healthy immune system, is an important energy source for the colon epithelium, plays an important role in maintaining intestinal barrier function through stimulation of tight junction integrity and mucin production
• Bacillus subtilis secretes many digestive enzymes such as protease, amylase, lipases, and cellulase which aid in food digestion. It also produces B group vitamins and vitamin K2 in the gut.
• B. subtilis is one of the most important probiotics for the treatment and prophylaxis of intestinal disorders in humans such as acute/chronic diarrhea and antibiotic-associated diarrhea (AAD)
• It has also been used to improve symptoms of IBS and IBD.